Located in the Monti this 4-star hotel is within a 10 minute walk to Piazza del Popolo. Rome city centre is within an easy 10 minute drive from the hotel.

The Twentyone Hotel staff are available 24/7 and can help with booking tours and tickets. The hotel operates a well-equipped business centre and offers conference facilities. Other facilities available to guests include luggage storage, a laundry service and a safe-deposit box. Other hotel facilities include a dry cleaning service, a concierge and meeting rooms.

All rooms feature a private bathroom including a bathrobe and amenities. Included in the room is a plasma / LCD TV, a safe and cable / satellite channels. A mini bar and a telephone are included in each room.